1. PURPOSE
To standardize rapid recognition and response to major hemorrhage, including timely activation of the Massive Transfusion Protocol (MTP), coordinated communication with blood bank, balanced component therapy, physiologic resuscitation (warming, calcium management, correction of coagulopathy), and safe escalation/transfer pathways, aligned with evidence-based best practices. (ACS)
2. SCOPE
Applies to all surgical/procedural areas (OR/NORA/PACU) and any location where life-threatening bleeding can occur, including obstetric, trauma, vascular, GI bleeding procedures, and postoperative hemorrhage.
3. DEFINITIONS
- Major hemorrhage: bleeding causing hemodynamic instability, rapidly falling Hb, or anticipated need for large volume transfusion.
- Massive transfusion: commonly defined as large-volume transfusion (e.g., ≥10 units RBC in 24 hours) and is operationalized via protocol activation criteria. (معلومات التكنولوجيا الحيوية)
- MTP: structured blood bank delivery and clinical management pathway. (ACS)
4. POLICY
- 4.1 The hospital shall maintain a written MTP with clear activation criteria, defined product delivery packs, responsibilities, and termination criteria. (ACS)
- 4.2 MTP activation shall trigger immediate multidisciplinary escalation (anesthesia, surgery/proceduralist, nursing, blood bank, lab) and continuous reassessment. (ACS)
- 4.3 All MTP activations require post-event review and debrief (I8) and data monitoring for improvement. (ACS)
5. PROCEDURES
5.1 Cognitive Aid + MTP Activation Card
Post the MTP activation steps and phone/pager numbers in OR core, PACU, NORA control areas, and on the hemorrhage cart.
5.2 Activation Criteria (Local Standard Must Define)
Activation should be based on clinical judgment and objective triggers (e.g., hemorrhagic shock, rapid ongoing blood loss, expected large transfusion requirement; trauma services may use scoring such as ABC in their system). (ACS)
5.3 Immediate Response Bundle (First Minutes)
- Call for help and announce “MAJOR HEMORRHAGE / ACTIVATE MTP.”
- Source control: surgical/procedural hemostasis steps escalate immediately.
- Access: establish/confirm large-bore IV/rapid infuser readiness; consider arterial line.
- Resuscitation priorities: prevent/treat hypothermia, acidosis, and coagulopathy (“lethal triad”).
- Lab strategy: send ABG/VBG, lactate, CBC, coagulation parameters, fibrinogen; use viscoelastic testing if available (local choice). (ACS)
5.4 Blood Bank Coordination and Component Therapy
Blood bank delivers products per MTP pack design. Balanced component strategies are widely recommended; trauma best practices commonly support plasma:RBC ratios between 1:1 and 1:2 with platelet support incorporated by protocol design. (ACS)
Define termination criteria to stop MTP when bleeding controlled and physiology stabilizing. (ACS)
5.5 Critical Adjuncts (Local Protocol Must Specify)
Calcium monitoring/replacement, warming strategy, antifibrinolytic use (e.g., TXA) when indicated by local guideline, and management of hypocalcemia/hyperkalemia as clinically indicated.
5.6 Hemorrhage Cart Readiness (Minimum)
Rapid infuser/blood warmer access, pressure bags, large-bore cannulas, Level 1/rapid warming supplies, point-of-care testing access (if used), and MTP cognitive aid.
5.7 Post-Event
ICU transfer criteria, ongoing monitoring, documentation of total blood products and complications, debrief (I8), and data submission to MTP audit dashboard.
6. RESPONSIBILITIES
- Anesthesia lead: resuscitation coordination, hemodynamic and temperature management, transfusion coordination with blood bank.
- Procedural/surgical lead: hemorrhage source control and operative decisions.
- Blood bank: product preparation/delivery and communication of inventory constraints. (ACS)
8. COMPLIANCE / AUDIT
- Quarterly review: time-to-MTP activation, time-to-first products, wastage, ratios achieved, hypothermia rate, and outcomes. (ACS)